Mebendazole (Vermox) interferes with a worm's ability to use which substance, resulting in the inability to reproduce and cell death?

Mebendazole works primarily by disrupting the energy metabolism of helminths, specifically by inhibiting their ability to utilize glucose. Glucose is the primary source of energy for many parasitic worms; without it, they cannot effectively produce ATP (adenosine triphosphate), which is crucial for numerous cellular processes, including reproduction and overall survival. By preventing the absorption of glucose, mebendazole effectively starves the worms, leading to their death.

This mechanism is particularly important because many anthelmintic agents target the structural components of worms or affect their neuromuscular functions. However, mebendazole's unique approach highlights its role as a metabolic inhibitor, making it effective against a wide range of intestinal parasites. Understanding the specific action of mebendazole underscores its importance in treating helminthic infections based on their energy requirements.