What is a common side effect associated with benzimidazole anthelmintics?

Benzimidazole anthelmintics, such as albendazole and mebendazole, often lead to gastrointestinal disturbances as a common side effect. These disturbances can manifest as nausea, vomiting, diarrhea, or abdominal pain. The mechanism behind these side effects is related to the action of benzimidazoles, which inhibit the polymerization of tubulin in helminths, leading to paralysis and subsequent elimination of the worms. Unfortunately, this same mechanism can irritate the gastrointestinal tract or disrupt normal intestinal motility and flora, resulting in the noted symptoms.

Other potential side effects from benzimidazole anthelmintics vary in frequency and severity, but gastrointestinal disturbances are notably more prevalent and can impact patient compliance with treatment. Understanding these side effects is crucial for managing and anticipating patient experiences during therapy.