What is the primary action mechanism of albendazole against parasites?

Albendazole primarily exerts its action against parasites by inhibiting glucose uptake. This mechanism is crucial because it depletes the energy stores of helminths (worms) and protozoa, leading to their eventual death. By interfering with the glucose metabolism, albendazole essentially starves the parasites, preventing them from carrying out their vital physiological functions, which ultimately results in their demise.

The effectiveness of albendazole highlights the reliance of many parasites on glucose for energy, which is not only fundamental for their survival but also distinguishes them from the human host, allowing for targeted intervention without harming the human cells. This mode of action is particularly important in treating infections caused by various types of worms, such as those caused by nematodes and cestodes.