What is the significance of calcium ion permeability in Praziquantel's action?

Praziquantel is an effective anthelmintic used primarily against trematodes and cestodes, and its mechanism of action is closely linked to its effect on calcium ion permeability in the cells of these parasites. When Praziquantel alters calcium ion permeability, it leads to an influx of calcium ions into the muscle cells of the parasite. This increased calcium level causes contractions of the muscles, ultimately leading to paralysis. The paralysis is significant because it results in the detachment of the parasite from the host's intestinal wall, making it easier for the host's immune system to eliminate the parasite or for the drug to flush it out of the system. Thus, the correct answer underscores the importance of calcium ion permeability in facilitating paralysis and detachment, contributing to the efficacy of Praziquantel as an anthelmintic agent.