Which anthelmintic agent is effective against both adult and larval stages of nematodes?

The effective anthelmintic agent against both adult and larval stages of nematodes is albendazole. This benzimidazole derivative works by inhibiting the polymerization of tubulin, which interferes with microtubule formation in the parasite. This mechanism disrupts essential cellular functions, ultimately leading to the death of the parasite.

Albendazole's spectrum of activity is broad, making it particularly valuable in treating various types of nematodal infections, including conditions caused by Ascaris, hookworms, and enterobiasis. Its effectiveness against both the adult and larval stages is crucial for adequate treatment since eliminating only adult parasites may allow the larval stages to mature and reinfect the host.

In contrast, thiabendazole and mebendazole primarily target adult worms, with less efficacy against larval forms. Pyrantel pamoate is effective against adult worms as well, but does not possess the same degree of efficacy against larvae. This characteristic of albendazole makes it a preferred option in managing nematode infections, ensuring a more comprehensive approach to treatment.