Which class of anthelmintics is most commonly used for treating nematodes?

Benzimidazoles are the most commonly used class of anthelmintics for treating nematodes due to their broad-spectrum efficacy and favorable safety profile. They work by binding to the beta-tubulin of the nematode’s cytoskeleton, inhibiting microtubule polymerization. This action effectively disrupts the worm's metabolism and reduces its ability to absorb glucose, leading to energy depletion and eventual death of the parasite.

This class includes well-known agents such as albendazole and mebendazole, which are frequently prescribed for various nematode infections in both humans and animals. The widespread use of benzimidazoles is attributed to their ability to target a range of nematodes, making them effective in treating different types of infections, including those caused by roundworms and whipworms.

Other classes like macrolides, while important in certain contexts (often used for their antibacterial properties), are less effective as anthelmintics. Imidazothiazoles, although effective against some nematodes, are not as commonly used as benzimidazoles in human medicine. Similarly, phenols are not a recognized mainstay in anthelmintic therapy for nematodes. Thus, ben