Which pre-illness health factor increases the risk for adverse effects when taking albendazole?

The choice of cimetidine as a pre-illness health factor that increases the risk for adverse effects when taking albendazole is correct due to the pharmacokinetic interactions between these two agents. Cimetidine is a known inhibitor of several cytochrome P450 enzymes, particularly CYP3A4. Albendazole is metabolized in the liver via this pathway. When cimetidine is administered concurrently with albendazole, it can lead to increased plasma concentrations of albendazole due to impaired metabolism.

The rise in albendazole levels in the bloodstream can heighten the risk of side effects associated with the drug, such as gastrointestinal complaints or hematologic abnormalities, by causing enhanced exposure to the drug over time. This underscores the importance of carefully considering drug interactions and individual patient factors when prescribing medications.

In contrast, smoking, a history of high blood pressure, and a dairy allergy do not have the same direct and significant impacts on the metabolism or efficacy of albendazole in a way that would lead to an increased risk of adverse effects as seen with cimetidine. Smoking may affect general health but does not specifically influence albendazole’s metabolism. High blood pressure does not inherently increase the risk of adverse drug reactions related to albend